Advancing circular economy performance indicators and their application in Spanish companies.

Current research on the circular economy (CE) reveals that, while the concept and its application have been extensively explored as shown in several case studies, the definition of tools and criteria measuring "circularity" of products, companies or regions are not well-defined. Therefore, indicators for measuring the different levels of a CE (micro, meso, and macro) should be a high priority for stakeholders (governments, companies, NGOs, civil society, etc.) in order to track progress on CE initiatives. However, the increasing interest on CE has caused a still open debate on the conceptualization of CE which hampers the creation of indicators based on a common conceptual framework. As a result, the absence of standard indicators to track progress on circularity is leading to contradiction and misunderstanding, which represents a challenge to the implementation of CE strategies. Thus, this study tries to address this gap by advancing a set of indicators adapted from existing indicators that guarantees simplicity and effectiveness, closely based on indicators proposed by government bodies. This research carried out an exploratory study to formulate the indicators requirements based on literature, refined through experts' opinion and then they were tested in Spanish companies located in the Basque Country region through an empirical work to assess this theory. A mix of research methods (e.g. semi-structured interviews and surveys) were used to seek applicability of CE indicators for organisations. The study showed that the proposed indicators currently used for assessing the CE at the macro level were applicable at the micro level based on companies' responses. This fact demonstrated that the indicators serve the purpose of being applicable to companies regardless of the type of economic activity they were in. Also, it shows that indicators used to monitor progress on CE at the macro level can be translated to the micro level. Consequently, it is recommended that the set of CE indicators focused on the methodology proposed in this study should be used across different industrial sectors in order to observe performance in companies to facilitate the transition to a CE model. (c) 2020 Elsevier Ltd. All rights reserved

Shortcomings of Transforming a Local Circular Economy System through Industrial Symbiosis: A Case Study in Spanish SMEs.

Defining the circular economy (CE) as a material and energy model coincides with the definition given by multiple authors in which Industrial Symbiosis (IS) has been deemed as a foundational strategy to support the implementation of the CE. The consumption of secondary materials is essential to achieve a successful transformation from a linear economy to a CE focused on IS practices. In this scenario, small and medium enterprises (SMEs) play a major role as stakeholders in developing CE systems as it is not possible to create this model with each company working in isolation. However, there is a lack of empirical studies on the role played by relevant local stakeholders such as individual firms interacting in the development of a local CE system. This study aimed to study the challenges that SMEs face in developing a CE system. A case study is selected as a research strategy using a mixed-method approach: a sequential quantitative (questionnaire) and qualitative (semi-structured interviews) data collection techniques were employed for this research. It was observed that an absence of inter-organisational collaboration and a misunderstanding of the roles played by SMEs may impede the implementation of a local CE system level

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Advancing circular economy performance indicators and their application in Spanish companies.

Current research on the circular economy (CE) reveals that, while the concept and its application have been extensively explored as shown in several case studies, the definition of tools and criteria measuring "circularity" of products, companies or regions are not well-defined. Therefore, indicators for measuring the different levels of a CE (micro, meso, and macro) should be a high priority for stakeholders (governments, companies, NGOs, civil society, etc.) in order to track progress on CE initiatives. However, the increasing interest on CE has caused a still open debate on the conceptualization of CE which hampers the creation of indicators based on a common conceptual framework. As a result, the absence of standard indicators to track progress on circularity is leading to contradiction and misunderstanding, which represents a challenge to the implementation of CE strategies. Thus, this study tries to address this gap by advancing a set of indicators adapted from existing indicators that guarantees simplicity and effectiveness, closely based on indicators proposed by government bodies. This research carried out an exploratory study to formulate the indicators requirements based on literature, refined through experts' opinion and then they were tested in Spanish companies located in the Basque Country region through an empirical work to assess this theory. A mix of research methods (e.g. semi-structured interviews and surveys) were used to seek applicability of CE indicators for organisations. The study showed that the proposed indicators currently used for assessing the CE at the macro level were applicable at the micro level based on companies' responses. This fact demonstrated that the indicators serve the purpose of being applicable to companies regardless of the type of economic activity they were in. Also, it shows that indicators used to monitor progress on CE at the macro level can be translated to the micro level. Consequently, it is recommended that the set of CE indicators focused on the methodology proposed in this study should be used across different industrial sectors in order to observe performance in companies to facilitate the transition to a CE model. (c) 2020 Elsevier Ltd. All rights reserved

Shortcomings of Transforming a Local Circular Economy System through Industrial Symbiosis: A Case Study in Spanish SMEs.

Defining the circular economy (CE) as a material and energy model coincides with the definition given by multiple authors in which Industrial Symbiosis (IS) has been deemed as a foundational strategy to support the implementation of the CE. The consumption of secondary materials is essential to achieve a successful transformation from a linear economy to a CE focused on IS practices. In this scenario, small and medium enterprises (SMEs) play a major role as stakeholders in developing CE systems as it is not possible to create this model with each company working in isolation. However, there is a lack of empirical studies on the role played by relevant local stakeholders such as individual firms interacting in the development of a local CE system. This study aimed to study the challenges that SMEs face in developing a CE system. A case study is selected as a research strategy using a mixed-method approach: a sequential quantitative (questionnaire) and qualitative (semi-structured interviews) data collection techniques were employed for this research. It was observed that an absence of inter-organisational collaboration and a misunderstanding of the roles played by SMEs may impede the implementation of a local CE system level

Convergencia de 4º hacia el TFG

Se trata de un proyecto piloto sobre el Trabajo Final de Grado. El alumno de Diseño ha utilizado en los tres primeros cursos una metodología de proyecto integrado, que hace converger el contenido de las diferentes materias hacia el proyecto propuesto por el profesor invitado. En esta primera edición del Trabajo Final de Grado, se ha planteado una innovación: el alumno elige voluntariamente el contenido del proyecto. El PID Convergencia4 ha hecho converger 11 asignaturas optativas y 2 obligatorias de 4º hacia los proyectos individuales de TFG. Es decir, no es una relación de cinco asignaturas con un proyecto como en cursos precedentes, sino de 13 asignaturas con 38 proyectos. Durante todo el curso, los alumnos han ido acumulando ideas, perspectivas y enfoques desde distintas asignaturas y han podido reflejarlos en sus TFG con naturalidad y acierto. De alguna manera, el TFG que supone 18 ECTS (30% de 4º curso), se ha visto ampliado con el enriquecimiento de los 30 ECTS optativos (50% del curso). Además, aunque inicialmente no habíamos previsto incluirlas en el PID, dos asignaturas obligatorias del segundo cuatrimestre (Estrategias de Comunicación y Web, y Business Management), también han influido directamente en los TFG, pues la mayoría de los alumnos ha incorporado estos contenidos a su TFG. De esta manera, el TFG de Diseño en la ETSAUN, se ha convertido en un trabajo casi anual, que sintetiza todo el aprendizaje adquirido por el alumno y sirve como carta de presentación para su trabajo profesional